​Articles in Malayalam:

1. കീമോ, റേഡിയേഷൻ തെറാപ്പികൾക്ക് ശേഷവും കാൻസർ തിരിച്ചുവരുന്നത് എന്തുകൊണ്ട്?......
Read more at: https://www.mathrubhumi.com/health/features/why-does-cancer-come-back-how-to-cope-with-cancer-recurrence-1.8555074?fbclid=IwZXh0bgNhZW0CMTEAAR0jlfRNG9yK7xttxor-r4oFtJdmM0QF0amCzp4zKfFKpvXpPuspRXVvIls_aem_rJoUnDnJ5wvkyknuaZUYWw

2. എന്താണ്  കാൻസർ?; ജീനോമിക്സിന്റെ വളർച്ചയും മാറുന്ന കാൻസർ ചികിത്സാരീതികളും......
Read more at: https://www.mathrubhumi.com/health/features/cancer-genomics-cancer-research-and-treatment-advances-1.9469814?fbclid=IwZXh0bgNhZW0CMTEAAR0SZHCJ75gN_wT7QDPPfJZZ-402tc_A_r6Lt3nvyyDPtXoiaWS0QFzlVX0_aem_yra-GUBpaCwq-7ritFRioA

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Research Articles:

1. Manu, Kanjoormana Aryan, M. D. Bronte, and Emilio Francesco Giunta.(ebook) "Reviews in Gastrointestinal Cancers." Frontiers in Oncology 13: 1252665

2. Prabha, Silpa, Sanjay Tamoli, Achuthan C. Raghavamenon, and Kanjoormana Aryan Manu. "Virgin Coconut Oil Alleviates Dextran Sulphate–Induced Inflammatory Bowel Disease and Modulates Inflammation and Immune Response in Mice." Journal of the American Nutrition Association (2023): 1-11.

3. Manu KA, Bronte F, Giunta EF. Editorial: Reviews in gastrointestinal cancers. Front Oncol. 2023 Jul 18;13:1252665. doi: 10.3389/fonc.2023.1252665. PMID: 37534244; PMCID: PMC10392844.

4. Devan AR, Nair B, Aryan MK, Liju VB, Koshy JJ, Mathew B, Valsan A, Kim H, Nath LR. Decoding Immune Signature to Detect the Risk for Early-Stage HCC Recurrence. Cancers (Basel). 2023 May 12;15(10):2729. doi: 10.3390/cancers15102729. PMID: 37345066; PMCID: PMC10216348.

5. Jose A, Bavetta MG, Martinelli E, Bronte F, Giunta EF, Manu KA. Hepatocellular Carcinoma: Current Therapeutic Algorithm for Localized and Advanced Disease. J Oncol. 2022 Dec 31;2022:3817724. doi: 10.1155/2022/3817724. PMID: 36624801; PMCID: PMC9825221. (Review) (Impact Factor: 4.501)

6. Kumar DP, Manu KA, Macha MA. Editorial: The role of non-coding RNAs in gastrointestinal cancer. Front Oncol. 2022 Nov 8;12:1056897. doi: 10.3389/fonc.2022.1056897. PMID: 36425552; PMCID: PMC9679618. (Editorial) (Impact Factor: 6.244)

7. Manu KA, Harikumar KB, Ishimoto T. Editorial: Targeting Pancreatic Cancer: Strategies and Hopes. Front Oncol. 2022 Mar 31;12:873682. doi: 10.3389/fonc.2022.873682. eCollection 2022. (Editorial) (Impact Factor: 6.244)

8. Chakrabhavi Dhananjaya Mohan , Chulwon Kim , Kodappully Sivaraman Siveen , Kanjoormana Aryan Manu , Shobith Rangappa , Arunachalam Chinnathambi , Sulaiman Ali Alharbi , Kanchugarakoppal S Rangappa , Alan Prem Kumar , Kwang Seok Ahn . Crocetin imparts antiproliferative activity via inhibiting STAT3 signaling in hepatocellular carcinoma. IUBMB Life 2021 Sep 12. doi: 10.1002/iub.2555. Online ahead of print. (Impact Factor: 3.224)

9. Chai, T.F#., Manu, K.A#., Casey, P.J. et al. (#First authors with equal contribution) Isoprenylcysteine carboxylmethyltransferase is required for the impact of mutant KRAS on TAZ protein level and cancer cell self-renewal. Oncogene 39, pages5373–5389(2020) (2020). https://doi.org/10.1038/s41388-020-1364-7 (Impact Factor: 9.687)

10. Manu KA, Cao PHA, Chai TF, Casey PJ, Wang M. p21cip1/waf1 Coordinate Autophagy, Proliferation and Apoptosis in Response to Metabolic Stress. Cancers (Basel). 2019 Aug 3;11(8). pii: E1112. doi: 10.3390/cancers11081112. Review. (Impact Factor: 6.639)

11. Shanmugam MK, Ahn KS, Lee JH, Kannaiyan R, Mustafa N, Manu KA, Siveen KS, Sethi G, Chng WJ, Kumar AP. Celastrol Attenuates the Invasion and Migration and Augments the Anticancer Effects of Bortezomib in a Xenograft Mouse Model of Multiple Myeloma. Front Pharmacol. 2018 May 3;9:365. doi: 10.3389/fphar.2018.00365. eCollection 2018. (Impact Factor: 4.4)

12. Manu KA, Chai TF, Teh JT, Zhu WL, Casey PJ, Wang M. Inhibition of Isoprenylcysteine Carboxylmethyltransferase Induces Cell-Cycle Arrest and Apoptosis through p21 and p21-Regulated BNIP3 Induction in Pancreatic Cancer. Molecular Cancer Therapeutics . 2017 May;16(5):914-923. doi: 10.1158/1535-7163.MCT-16-0703. Epub 2017 Feb 6. PubMed PMID: 28167504. (Impact Factor:6.261 )

13. Manu KA, Shanmugam MK, Ramachandran L, Li F, Siveen KS, Chinnathambi A, Zayed ME, Alharbi SA, Arfuso F, Kumar AP, Ahn KS, Sethi G.Isorhamnetin augments the anti-tumor effect of capeciatbine through the negative regulation of NF-κB signalling cascade in gastric cancer. Cancer Lett. 2015 Jul 10;363(1):28-36. doi: 10.1016/j.canlet.2015.03.033. Epub 2015 Mar 28. (Impact Factor: 7.36)

14. Poyil Pratheeshkumar, Young-Ok Son, Preethi Korangath, Kanjoormana Aryan Manu, and Kodappully Sivaraman Siveen. Phytochemicals in Cancer Prevention and Therapy. Volume 2015, Article ID 324021, 2 pages (Impact Factor: NA)

15. Kanjoormana A. Manu, Muthu K. Shanmugam, Feng Li1, Luxi Chen, Kodappully Sivaraman Siveen, Kwang Seok Ahn, Alan Prem Kumar Gautam Sethi.. Simvastatin sensitizes human gastric cancer xenograft in nude mice to capecitabine by suppressing nuclear factor-kappa B regulated gene products, Journal of Molecular Medicine (Berl). 2014 Mar;92(3):267-76. (Impact Factor: 4.75)

16. Manu KA, Shanmugam MK, Ong TH, Subramaniam A, Siveen KS, Perumal E, Samy RP, Bist P, Lim LH, Kumar AP, Hui KM, Sethi G. Emodin suppresses migration and invasion through the modulation of CXCR4 expression in an orthotopic model of human hepatocellular carcinoma. PLoS One. 2013;8(3):e57015. doi: 10.1371/journal.pone.0057015. Epub 2013 Mar 5. (Impact Factor:2.7)

17. Kanjoormana Aryan Manu, Muthu K. Shanmugam, Lalitha Ramachandran, Feng Li, Chee Wai Fong, Alan Prem Kumar, Patrick Tan, Gautam Sethi. First evidence that γ-tocotrienol inhibits the growth of human gastric cancer and chemosensitizes it to capecitabine in a xenograft mouse model through the modulation of NF-κB pathway. Clinical Cancer Research 2012 Apr 15;18(8):2220-9. Epub 2012 Feb 20. (Impact Factor: 13.8)

18. Kanjoormana Aryan Manu,  Hui  Sin Hay, Peramaiyan Rajendran, Muthu K Shanmugam, Feng Li,  Radhamani Kannaiyan,  Shireen Vali,  Shweta Kapoor, Bhargavi  Ramesh,  Pradeep Bist,  Evelyn S C Koay,  Lina H.K Lim,  Kwang  Seok Ahn, Alan Prem Kumar, and Gautam Sethi * Plumbagin inhibits invasion and migration of breast and gastric cancer cells by downregulating the expression of chemokine receptor CXCR4. . Mol Cancer. 2011 Sep 1;10:107. (Impact Factor:41.444)

19. Radhamani Kannaiyan#, Kanjoormana Aryan Manu # (Equal First author), Luxi Chen , Feng Li1, Peramaiyan Rajendran, Arul Joe Win1, Alan Prem Kumar, Gautam Sethi, Celastrol inhibits tumor cell proliferation and promotes apoptosis through the activation of c-Jun N-Terminal Kinase, suppression of Akt pathway, and downregulation of antiapoptotic gene products. Apoptosis 2011 Oct;16(10):1028-41. (Impact Factor: 4.543)

20. Muthu K Shanmugam#, Kanjoormana Aryan Manu # (Equal First author), Lalitha Ramachandran, Tina H.Ong2,Rohit Surana, Pradeep Bist4, Lina H.K Lim, Alan Prem Kumar, Kam M.Hui and Gautam Sethi Inhibition of CXCR4/CXCL12 signaling axis by ursolic acid leads to suppression of metastasis in transgenic adenocarcinoma of mouse prostate model. International Journal of Cancer 2011 Oct 1;129(7):1552-63. doi: 10.1002/ijc.26120. Epub 2011 Jul 20 (Impact Factor: 5.145)

21. Subramaniam A, Loo SY, Rajendran P, Manu KA, Perumal E, Li F, Shanmugam MK, Siveen KS, Park JI, Ahn KS, Hui KM, Kumar AP, Sethi G.An anthraquinone derivative, emodin sensitizes hepatocellular carcinoma cells to TRAIL induced apoptosis through the induction of death receptors and downregulation of cell survival proteins. Apoptosis 18 (10), 1175-1187, 2013 (Impact Factor: 4.453)

22. Maralinganadoddi Panchegowda Sadashiva, Basappa, Sivananju Najundaswamy, Feng Li, Kanjoormana Aryan Manu et al, Anticancer activity of novel dibenzo[b,f]azepine tethered isoxazoline derivatives. BMC Chemical Biology 2012, 12:5. (Impact Factor: NA)

23. Ramachandran L, Manu KA, Shanmugam MK, Li F, Siveen KS, Vali S, Kapoor S, Abbasi T, Surana R, Smoot DT, Ashktorab H, Tan P, Ahn KS, Yap CW, Kumar AP, Sethi G. Isorhamnetin inhibits proliferation, invasion, and induces apoptosis through the modulation of peroxisome proliferator-activated receptor-gamma activation pathway in gastric cancer. Journal of Biological Chemistry 287 (45), 38028-38040 2012 (Impact Factor: 4.106)

24. Kuttan G, Pratheeshkumar P, Manu K.A,. Inhibition of tumor progression by naturally occurring terpenoids. Pharmaceutical Biology Pharm Biol. 2011 Oct;49(10):995-1007.( Review ) (Impact Factor: 2.14))

25. Rajendran P, Li F, Aryan MK, Shanmugam MK, Loo SY, Kumar AP, Sethi G. γ-Tocotrienol is a novel inhibitor of constitutive and inducible STAT3 signalling pathway in human hepatocellular carcinoma: potential role as an anti-proliferative, pro-apoptotic and chemosensitizing agent. British journal of pharmacology 2010 Dec. ;163(2):283-98 (Impact Factor: 7.73)

26. Kanjoormana Manu, Girija Kuttan. Antiangiogenic activity of Ursolic acid. Integrative cancer therapies 2010 Jun; 9(2) (Impact Factor: 2.379)

27. K.A Manu, Girija Kuttan. Punarnavine induces apoptosis in B16F-10 melanoma cells by inhibiting NF-kB Signaling. Asian Pacific Journal of Cancer Prevention. 2009;10(6):1031-7. (Impact Factor: NA )

28. K.A. Manu, Girija Kuttan. Immunomodulatory activities of Punarnavine, an alkaloid from Boerhaavia diffusa. Immunopharmacology and Immunotoxicology 2009;31(3):377-87. (Impact Factor: 2.352)

29. K.A. Manu, Girija Kuttan. Anti-metastatic potential of Punarnavine, an alkaloid from Boerhaavia diffusa.Linn.  Immunobiology (2009) 214(4):245-55. (Impact Factor: 2.788)

30. K.A. Manu, Girija Kuttan. Ursolic acid induces apoptosis by activating p53 and caspase-3 gene expressions and suppressing NF-κB mediated activation of bcl-2 in B16F-10melanoma cells. International Immunopharmacology (2008) 8, 974–981. (Impact Factor: 3.943)

31. K.A. Manu, Girija Kuttan. Boerhaavia diffusa stimulates cell-mediated immune response by upregulating IL-2 and downregulating the pro-inflammatory cytokines and GM-CSF in b16f-10 metastatic melanoma bearing mice Journal of experimental therapeutics and oncology, (2008), 7; 17-29. (Impact Factor: NA)

32. K. A. Manu and Girija Kuttan, 'Effect of Punarnavine, an Alkaloid from Boerhaavia diffusa, on Cell-Mediated Immune Responses and TIMP-1 in B16F-10 Metastatic Melanoma-Bearing Mice', Immunopharmacology and Immunotoxicology, (2007) 29:3, 569 – 586. (Impact Factor: 2.352)

33. K.A. Manu, P.V. Leyon and Girija Kuttan Studies on the Protective Effects of Boerhaavia diffusa L. Against Gamma Radiation Induced Damage in Mice, Integr Cancer Ther 2007; 6; 381 (Impact Factor: 2.379)

SEMINARS/ Seminar proceedings

1. Invited talk, Molecular Methods and Precision Oncology- an Introductory Course, Clinical Research Unit, Amala Oncology and Roche Foundation medicine, 9th Nov 2022, Amala Institute of medical Sciences, Thrissur.

2. Invited talk, Pro. Yesudhasan Memorial day lecture, Dept. of Zoology, St. Thomas’ College Thrissur, 2022

3. Invited Talk, Two day Workshop on Methodological Aspects of Genetic Diseases. PG and Research Dept of Botany, Mercy College, Palakkad, 25th Feb 2022.

4. Invited talk, International seminar on Lifestyle Diseases, Feb 18, 2020 National College, Manacaud, Thiruvanandapuram, Kerala, India

5. Manu KA, Chai TF, Teh JT, Zhu WL, Casey PJ, Wang M. Targeting post prenylation processing enzymes in Pancreatic cancer, Annual conference, Indian Association for Cancer research Feb 5-7, Thiruvanandapuram, Kerala, India

6. Invited talk on “ Targeting Prenylation in pancreatic cancer “ Rev Father Isaac Alappat Endowment Seminar. Christ College, Irinjalakuda, Thrissur, Kerala, India 13th December 2018.

7. Manu KA, Chai TF, Teh JT, Zhu WL, Casey PJ, Wang M. Targeting ICMT in Pancreatic cancer. American Association for Cancer Research (AACR) Annual meeting 2018, McCormick Place, Chicago, IL, USA. From 14th April 2018 to 18th April 2018

8. Invited talk on Targeting post-prenylation processing enzymes in cancer. St. Thomas’ College, Thrissur, Kerala, India. Research Dept. Of Botany, Golden Jubilee lecture Series. December 2017.

9. Invited talk on “Gamma-tocotrienol potentiates the antitumor activity of capecitabine in vitro and in xenograft mouse model of human gastric cancer”. Second International Conference on Holistic Medicine (ICHM-2011) Kottayam, Kerala, India, Sept 2011.

10. Invited talk on “ Simvastasin Sensitizes Gastric cancer towards Capecitabine”. International Seminar o Biotechnology.  Karunya University, Coimbatore. TN, India. December 2011.

11. Manu KA, Chai TF, Teh JT, Zhu WL, Casey PJ, Wang M. Inhibition of ICMT Induces Cell-Cycle Arrest and Apoptosis through p21 and p21-Regulated BNIP3 Induction in Pancreatic Cancer. DUNES Symposium, DUKE-NUS Medical School, Singapore, 30th October 2017.

12. R Kannaiyan, MK Aryan, MK Shanmugam, F Li, G Sethi Celastrol Overcomes Chemoresistance in Vitro and Potentiates the Effect of Bortezomib Against Human Multiple Myeloma in Nude Mice Model Blood 120 (21), 5017-5017 (Americal Society of Haematology Annual Meeting)

13. Lalitha Ramachandran1, Manu Kanjoormana Aryan1, Chen Luxi2, Li Feng1, Peramaiyan Rajendran1, Chun Wei Yap1, Alan Prem Kumar2, and Gautam Sethi1 Abstract 1978: Isorhamnetin modulates PPAR activation pathway leading to the suppression of proliferation, invasion and induction of apoptosis in gastric cancer. Proceedings: AACR 103rd Annual Meeting 2012-- Mar 31-Apr 4, 2012; Chicago, IL. Cancer Research: April 15, 2012; Volume 72, Issue8, Supplement1 doi:   10.1158/1538-7445.AM2012-1978.

14. Nanjunda Swamy S, Raghu Ningegowda, Rajendran P, Basappa, Feng Li1, Ranjith. S, Manu KA, Shanmugam MK, Rangappa KS, Priya BS, Lim LH , Alan Prem Kumar and Gautam Sethi. Identification of a novel 4, 6-disubstituted-1, 2, 4-triazolo-1, 3, 4-thiadiazole derivative that can inhibit proliferation, and induce apoptosis by modulating  NF-κB activation in tumor cells. Poster presentation. Mitochondria, Apoptosis and Cancer Conference, National University of Singapore. Singapore.  27th -29th October, 2011.

15. Manu Aryan, Muthu K Shanmugham, Lalitha Ramachandran and Gautam Sethi. “ Potential role of gamma-tocotrienol as a chemosensitizer in xenograft mouse model of human gastric cancer”  BIT's 4th World Cancer Congress, May 22-25, 2011 Dalian, China

16. Manu Aryan, Muthu K Shanmugham, Lalitha Ramachandran and Gautam Sethi. Poster “Gamma-Tocotrienol, A Multitargeted Agent, Can Enhance Antitumor Activity Of Capecitabine In Vitro And In Xenograft Mouse Model Of Human Cancer.  9th International Gastric Cancer Congress (IGCC 2011) 20 to 23 April 2011. Seoul, Korea (South).

17. Oral presentation on “Gamma-tocotrienol potentiates the antitumor activity of capecitabine in vitro and in xenograft mouse model of human gastric cancer”. Manu Aryan, Muthu K Shanmugham, Lalitha Ramachandran and Gautam Sethi IACR Satellite meeting “Inhibition of Tumor progression” Amala Cancer Research Centre, Thrissur, Kerala, India, Feb 2011.

18. Manu KA, Girija Kuttan. Poster on “Glycyrrhizic acid induces apoptosis in B16F-10 melanoma cells by inhibiting NF- κB induced Bcl-2 activation and activating the pro-apoptotic signaling pathways mediated by p53 and caspase-3” in the 2nd International Symposium on Translational Research, Lonavala, Mumbai. India. December 2007.

19. Manu KA, Girija Kuttan. Poster on “Anti-angiogenic activity of Ursolic acid” in the International Symposium on Novel Strategies for Targeted Prevention and Treatment of Cancer. School of Life Sciences, Jawaharlal Nehru University, New Delhi, India. December, 2008.